A new soft, wireless implant may someday help people who suffer from overactive bladder get through the day with fewer bathroom breaks.
The implant harnesses a technique for controlling cells with light, known as optogenetics, to regulate nerve cells in the bladder. In experiments in rats with medication-induced overactive bladders, the device alleviated animals’ frequent need to pee, researchers report online January 2 in Nature.
Although optogenetics has traditionally been used for manipulating brain cells to study how the mind works, the new implant is part of a recent push to use the technique to tame nerve cells throughout the body (SN: 1/30/10, p. 18). Similar optogenetic implants could help treat disease and dysfunction in other organs, too. “I was very happy to see this,” says Bozhi Tian, a materials scientist at the University of Chicago not involved in the work. An estimated 33 million people in the United States have overactive bladders. One available treatment is an implant that uses electric currents to regulate bladder nerve cells. But those implants “will stimulate a lot of nerves, not just the nerves that control the bladder,” Tian says. That can interfere with the function of neighboring organs, and continuous electrical stimulation can be uncomfortable.
The new optogenetic approach, however, targets specific nerves in only one organ and only when necessary. To control nerve cells with light, researchers injected a harmless virus carrying genetic instructions for bladder nerve cells to produce a light-activated protein called archaerhodopsin 3.0, or Arch. A stretchy sensor wrapped around the bladder tracks the wearer’s urination habits, and the implant wirelessly sends that information to a program on a tablet computer. If the program detects the user heeding nature’s call at least three times per hour, it tells the implant to turn on a pair of tiny LEDs. The green glow of these micro light-emitting diodes activates the light-sensitive Arch proteins in the bladder’s nerve cells, preventing the cells from sending so many full-bladder alerts to the brain. John Rogers, a materials scientist and bioengineer at Northwestern University in Evanston, Ill., and colleagues tested their implants by injecting rats with the overactive bladder–causing drug cyclophosphamide. Over the next several hours, the implants successfully detected when rats were passing water too frequently, and lit up green to bring the animals’ urination patterns back to normal.
Shriya Srinivasan, a medical engineer at MIT not involved in the work, is impressed with the short-term effectiveness of the implant. But, she says, longer-term studies may reveal complications with the treatment.
For instance, a patient might develop an immune reaction to the foreign Arch protein, which would cripple the protein’s ability to block signals from bladder nerves to the brain. But if proven safe and effective in the long term, similar optogenetic implants that sense and respond to organ motion may also help treat heart, lung or muscle tissue problems, she says.
Optogenetic implants could also monitor other bodily goings-on, says study coauthor Robert Gereau, a neuroscientist at Washington University in St. Louis. Hormone levels and tissue oxygenation or hydration, for example, could be tracked and used to trigger nerve-altering LEDs for medical treatment, he says.
There’s no sorrier sight than a puking preschooler. That’s the conclusion I recently reached around 2 a.m. as my poor 4-year-old heaved into the dim abyss. Luckily, her bout with the stomach flu was brief, and she was feeling better by the next day.
Stomach flu, also known as gastroenteritis, is a common affliction caused by bacteria or viruses that inflame the gut. Though mercifully short, the misery this brings is complete, for both the sufferer and the person charged with scrubbing chunks out of sheets, carpet and a stuffed toy cupcake. So when presented with something that could potentially cut short the puking, any parent would jump at the chance. That’s the promise of probiotics, “good” bacteria (typically in pill form) that some people think might help restore the irritated gut and get kids feeling better faster. But according to two big studies (here and here) of puking kids and probiotics, parents should save their money for something else.
For both studies, scientists studied kids ages 3 months to 4 years who came to an emergency department with acute gastroenteritis. In addition to receiving regular care, these kids took either a probiotic or placebo for five days. Then the researchers tallied up the kids’ symptoms to see if those who got the live bugs fared better than those who received a placebo. Long story short, the scientists found absolutely no differences.
The trials used different bacteria as probiotics. One used Lactobacillus rhamnosus, sold as products such as Culturelle, and the other used that bacteria plus Lactobacillus helveticus, a combination sold as Lacidofil. Neither of the formulations cut puking or other symptoms short. The kids had about the same duration of diarrhea (about two days) and missed the same amount of daycare (two days on average).
As far as studies go, these results, both published November 22 in the New England Journal of Medicine, are pretty clear: Probiotics didn’t help puking kids feel better faster. Of course, it’s possible that certain types of probiotics are good for other things, as an editorial in the same issue of the NEJM points out. Scientists have been studying whether probiotics can curb colic in babies, with some hints that helpful bacteria may reduce crying in breastfed babies (though the jury is still out). Other bacteria might also help newborns at risk of developing dangerous infections, as a recent study on babies in rural India suggests.
But when it comes to gastroenteritis in kids, probiotics’ benefits don’t seem to be there. If you’re desperate and willing to throw money at the problem, go ahead and buy your poor puking kid some probiotics. There’s no evidence they hurt, and it might make you feel like you’re doing something. Still, you’re probably better off spending your money on juice and popsicles.
Data from NASA’s now-defunct Cassini spacecraft show that five odd-shaped moons embedded in Saturn’s rings are different colors, and that the hues come from the rings themselves, researchers report. That observation could help scientists figure out how the moons were born.
“The ring moons and the rings themselves are kind of one and the same,” says planetary scientist Bonnie Buratti of NASA’s Jet Propulsion Laboratory in Pasadena, Calif. “For as long as the moons have existed, they’ve been accreting particles from the rings.” Saturn has more than 60 moons, but those nearest to the planet interact closely with its main band of rings. Between December 2016 and April 2017, Cassini passed close to five of these ring-dwelling moons: ravioli-shaped Pan and Atlas (SN Online: 3/10/17), ring-sculpting Daphnis and Pandora (SN: 9/2/17, p. 16) and potato-shaped Epimetheus. The flybys brought Cassini between two and 10 times closer to the moons than it had ever been, before the spacecraft deliberately crashed into Saturn in September 2017 (SN Online: 9/15/17).
Examining those close-ups, Buratti and her colleagues noticed that the moons’ colors vary depending on the objects’ distances from Saturn. And the moon hues are similar to the colors of the rings that the objects are closest to, the team reports online March 28 in Science. Close-in Pan was the reddest moon, while the farthest-out Epimetheus was the bluest. The researchers think the red material comes from Saturn’s dense main rings, and mostly consists of organics and iron (SN Online: 10/4/18). The blue material is probably water ice from Saturn’s more distant E ring, which is created by plumes erupting from the larger, icy moon Enceladus. The team thinks that the rings are continually depositing material onto the moons. “It’s an ongoing process,” Buratti says. She notes that “skirts” of material at Atlas and Pan’s equators are probably made of accreted ring debris, too.
The overall similarity between the moons and rings led the researchers to conclude that these small moons are leftover shards of a destructive event that created the rings in the first place. But it’s unknown whether that event was a collision between long-gone, larger moons, the shredding of one moon by Saturn’s gravity, or some other occurrence (SN: 1/20/18, p. 7).
Saturn, its rings and its moons are “very dynamic,” says planetary scientist Matija Ćuk of the SETI Institute in Mountain View, Calif. The idea that the rings are still shedding material onto the moons today “sounds perfectly reasonable.” He isn’t sure the moons formed at the same time as the rings, though. It’s possible “they formed from the rings since that catastrophic event,” he says.
Editor’s note: On April 10, the Event Horizon Telescope collaboration released a picture of the supermassive black hole at the center of galaxy M87. Read the full story here.
We’re about to see the first close-up of a black hole.
The Event Horizon Telescope, a network of eight radio observatories spanning the globe, has set its sights on a pair of behemoths: Sagittarius A*, the supermassive black hole at the Milky Way’s center, and an even more massive black hole 53.5 million light-years away in galaxy M87 (SN Online: 4/5/17). In April 2017, the observatories teamed up to observe the black holes’ event horizons, the boundary beyond which gravity is so extreme that even light can’t escape (SN: 5/31/14, p. 16). After almost two years of rendering the data, scientists are gearing up to release the first images in April.
Here’s what scientists hope those images can tell us.
What does a black hole really look like? Black holes live up to their names: The great gravitational beasts emit no light in any part of the electromagnetic spectrum, so they themselves don’t look like much.
But astronomers know the objects are there because of a black hole’s entourage. As a black hole’s gravity pulls in gas and dust, matter settles into an orbiting disk, with atoms jostling one another at extreme speeds. All that activity heats the matter white-hot, so it emits X-rays and other high-energy radiation. The most voraciously feeding black holes in the universe have disks that outshine all the stars in their galaxies (SN Online: 3/16/18). The EHT’s image of the Milky Way’s Sagittarius A, also called SgrA, is expected to capture the black hole’s shadow on its accompanying disk of bright material. Computer simulations and the laws of gravitational physics give astronomers a pretty good idea of what to expect. Because of the intense gravity near a black hole, the disk’s light will be warped around the event horizon in a ring, so even the material behind the black hole will be visible. And the image will probably look asymmetrical: Gravity will bend light from the inner part of the disk toward Earth more strongly than the outer part, making one side appear brighter in a lopsided ring.
Does general relativity hold up close to a black hole? The exact shape of the ring may help break one of the most frustrating stalemates in theoretical physics.
The twin pillars of physics are Einstein’s theory of general relativity, which governs massive and gravitationally rich things like black holes, and quantum mechanics, which governs the weird world of subatomic particles. Each works precisely in its own domain. But they can’t work together.
“General relativity as it is and quantum mechanics as it is are incompatible with each other,” says physicist Lia Medeiros of the University of Arizona in Tucson. “Rock, hard place. Something has to give.” If general relativity buckles at a black hole’s boundary, it may point the way forward for theorists.
Since black holes are the most extreme gravitational environments in the universe, they’re the best environment to crash test theories of gravity. It’s like throwing theories at a wall and seeing whether — or how — they break. If general relativity does hold up, scientists expect that the black hole will have a particular shadow and thus ring shape; if Einstein’s theory of gravity breaks down, a different shadow.
Medeiros and her colleagues ran computer simulations of 12,000 different black hole shadows that could differ from Einstein’s predictions. “If it’s anything different, [alternative theories of gravity] just got a Christmas present,” says Medeiros, who presented the simulation results in January in Seattle at the American Astronomical Society meeting. Even slight deviations from general relativity could create different enough shadows for EHT to probe, allowing astronomers to quantify how different what they see is from what they expect. Do stellar corpses called pulsars surround the Milky Way’s black hole? Another way to test general relativity around black holes is to watch how stars careen around them. As light flees the extreme gravity in a black hole’s vicinity, its waves get stretched out, making the light appear redder. This process, called gravitational redshift, is predicted by general relativity and was observed near SgrA* last year (SN: 8/18/18, p. 12). So far, so good for Einstein.
An even better way to do the same test would be with a pulsar, a rapidly spinning stellar corpse that sweeps the sky with a beam of radiation in a regular cadence that makes it appear to pulse (SN: 3/17/18, p. 4). Gravitational redshift would mess up the pulsars’ metronomic pacing, potentially giving a far more precise test of general relativity.
“The dream for most people who are trying to do SgrA* science, in general, is to try to find a pulsar or pulsars orbiting” the black hole, says astronomer Scott Ransom of the National Radio Astronomy Observatory in Charlottesville, Va. “There are a lot of quite interesting and quite deep tests of [general relativity] that pulsars can provide, that EHT [alone] won’t.”
Despite careful searches, no pulsars have been found near enough to SgrA* yet, partly because gas and dust in the galactic center scatters their beams and makes them difficult to spot. But EHT is taking the best look yet at that center in radio wavelengths, so Ransom and colleagues hope it might be able to spot some.
“It’s a fishing expedition, and the chances of catching a whopper are really small,” Ransom says. “But if we do, it’s totally worth it.” How do some black holes make jets? Some black holes are ravenous gluttons, pulling in massive amounts of gas and dust, while others are picky eaters. No one knows why. SgrA* seems to be one of the fussy ones, with a surprisingly dim accretion disk despite its 4 million solar mass heft. EHT’s other target, the black hole in galaxy M87, is a voracious eater, weighing in at between about 3.5 billion and 7.22 billion solar masses. And it doesn’t just amass a bright accretion disk. It also launches a bright, fast jet of charged subatomic particles that stretches for about 5,000 light-years.
“It’s a little bit counterintuitive to think a black hole spills out something,” says astrophysicist Thomas Krichbaum of the Max Planck Institute for Radio Astronomy in Bonn, Germany. “Usually people think it only swallows something.”
Many other black holes produce jets that are longer and wider than entire galaxies and can extend billions of light-years from the black hole. “The natural question arises: What is so powerful to launch these jets to such large distances?” Krichbaum says. “Now with the EHT, we can for the first time trace what is happening.”
EHT’s measurements of M87’s black hole will help estimate the strength of its magnetic field, which astronomers think is related to the jet-launching mechanism. And measurements of the jet’s properties when it’s close to the black hole will help determine where the jet originates — in the innermost part of the accretion disk, farther out in the disk or from the black hole itself. Those observations might also reveal whether the jet is launched by something about the black hole itself or by the fast-flowing material in the accretion disk.
Since jets can carry material out of the galactic center and into the regions between galaxies, they can influence how galaxies grow and evolve, and even where stars and planets form (SN: 7/21/18, p. 16).
“It is important to understanding the evolution of galaxies, from the early formation of black holes to the formation of stars and later to the formation of life,” Krichbaum says. “This is a big, big story. We are just contributing with our studies of black hole jets a little bit to the bigger puzzle.”
Editor’s note: This story was updated April 1, 2019, to correct the mass of M87’s black hole; the entire galaxy’s mass is 2.4 trillion solar masses, but the black hole itself weighs in at several billion solar masses. In addition, the black hole simulation is an example of one that uphold’s Einstein’s theory of general relativity, not one that deviates from it.
As the morning sun peeked through the trees, Rodger Kram readied himself for the coming marathon. But not the kind he used to run.
Kram, a physiologist at the University of Colorado Boulder, stood next to undergrad James Wilson at the end of a rural dirt road. Each donned a strap of nylon webbing onto his head. Attached to the bottom of their straps — called tumplines — a log rested horizontally across the duo’s lower backs. The pair was about to embark on a 25-kilometer trek to replicate how the ancient people of Chaco Canyon may have transported timber around 1,000 years ago (SN: 5/17/17). By the end of the day, their successful journey suggested that it would have taken just a few days for three people with tumplines to carry a full-size timber to Chaco, Kram, Wilson and colleagues reported on February 22 in the Journal of Archaeological Science: Reports.
Located in the northwest corner of New Mexico, Chaco Canyon is home to grand structures built between A.D. 850 and 1200. Multistoried stone buildings called great houses had roofs with timber beams about 5 meters long and 22 centimeters in diameter. The site contained at least 200,000 timbers of this size. But the wood came from forests more than 75 kilometers away (SN: 9/26/01). Load-pulling animals and wheels weren’t there at the time, and the timbers don’t appear to have been dragged. Scientists are puzzled by how the ancient people, ancestors of modern-day Diné and Pueblo peoples, moved the large timbers.
A 1986 study suggested that each log used as a beam had a mass of 275 kilograms. But Kram suspected this number couldn’t be correct.
In 2016, he cut a section of a tree outside of his house — ponderosa pine, the same species used in Chaco — and weighed it on his bathroom scale. He then extrapolated that a 5-meter-long timber would be closer to 90 kilograms. This revelation led to a 2022 study recalculating the masses of the Chaco Canyon timbers as between 85 and 140 kilograms.
“As soon as we figured out that the weight was reasonable, I wanted to carry them,” Kram says.
He and Wilson proposed that tumplines could have been used to transport the timbers. These head straps have been found on every inhabited continent and are thought to have been used since at least around 2,000 years ago. They are still widely used to carry heavy loads, such as by professional porters in Nepal. A tumpline is placed on the crown of the head — to be in line with the cervical spine — with the attached cargo resting on the small of the back. While there is no evidence that the people of Chaco used tumplines to haul timbers, there is proof that they used them to transport other items, like water vessels.
To see if tumpline timber transportation was humanly possible, Kram and Wilson trained for three months during the summer of 2020, gradually increasing their load weight and walk duration. Strangers who passed by couldn’t hide their confusion.
On the final day, the pair walked 25 kilometers while carrying a ponderosa pine that had been air-dried, which is how the people of Chaco may have prepared timbers. The 60-kilogram log was 2.5 meters long and 24 centimeters in diameter. The entire trek took almost 10 hours, and the weight of the full timber only slightly slowed the duo’s pace.
“I felt happy at the end that it was proved feasible, and that the 132-pound log we shared was off our necks,” says Wilson, now a medical student at the University of Colorado School of Medicine in Aurora. But “I never really doubted that we could do it.”
In the classic fairy tale, Hansel and Gretel dropped bread crumbs while walking through a treacherous forest so they wouldn’t lose their way. Rovers may one day use a similar trick to traverse other planets without losing their data.
Typically, if a rover permanently loses communication during a mission, all the information that it has gathered is lost. To avoid this, researchers suggest using a multi-rover system in which a smaller rover piggybacks on a larger “mother rover.” The smaller rover would then venture into any especially uncertain territory, such as a cave or lava tubes, deploying sensors the size of an AirPods case like bread crumbs as it goes. The sensors could then communicate with each other via a wireless network and funnel any collected data back to the mother rover, theoretical physicist Wolfgang Fink and colleagues propose February 11 in Advances in Space Research. As proof of concept, the team built prototype sensors that communicate via Wi-Fi.
It’s not that the smaller rover would be following the “bread crumbs” back the way it came. Instead, “we use [the sensors] for the data to find its way communication-wise out of the cave to the mother rover,” says Fink, of the University of Arizona in Tucson.
The technology could also be useful here on Earth, especially after a natural disaster such as an earthquake. A rover could be sent with the deployable sensors into rubble where it’s too dangerous for people to perform search-and-rescue missions (SN: 12/3/14).
The bread crumb–like communication network could allow researchers to “cater to the essence of scientific exploration,” Fink says, by allowing rovers to overcome some of the constraints posed by tricky terrain. “To get to the real exciting science, you most of the time have to go to exotic places, hard-to-get-to places.”
An uncomfortable truth is that there is another influenza pandemic in humankind’s future. Whether it will be a relative of the lethal avian flu strain currently wreaking havoc in bird populations around the globe is anyone’s guess.
Because the virus, called H5N1, can be deadly to birds, mammals and people, researchers closely monitor reports of new cases. Worryingly, a new variant of H5N1 that emerged in 2020 has not only spread farther than ever before among birds, but has also spilled over into other animals, raising the specter of a human outbreak (SN: 12/12/22).
The variant was linked to a seal die-off in Maine last summer. In October, there was an H5N1 outbreak on a mink farm in Spain, researchers reported in January in Eurosurveillance. (It’s unclear how the mink were exposed, but the animals were fed poultry by-products.) Sea lions off the coast of Peru and wild bears, foxes and skunks, which prey upon or scavenge birds, in the United States and Europe have also tested positive for the virus.
Globally, hundreds of millions of domestic poultry have been culled or died from the new variant. It’s also likely that millions of wild birds have died, though few governmental agencies are counting, says Michelle Wille a viral ecologist at the University of Sydney who studies avian influenza. “This virus is catastrophic for bird populations.”
A handful of human cases have also been reported, though there’s no evidence that the virus is spreading among people. Of seven cases, six people recovered and one person from China died. In February, health officials in China reported an eighth case in a woman whose current condition is unknown.
What’s more, four of the reported human cases — including a U.S. case from Colorado and two workers linked to the Spanish mink farm — were in people who didn’t have any respiratory symptoms. That leaves open the possibility that those people were not truly infected. Instead, tests may have picked up viral contamination, say in the nose, that the people breathed in while handling infected birds.
The impossibility of predicting which avian influenza viruses might make the jump to people and spark an outbreak is in part related to knowledge gaps. These bird pathogens don’t typically easily infect or circulate among mammals including humans. And scientists don’t have a full grasp on how these viruses might need to change for human transmission to occur.
For now, it’s encouraging that so few people have gotten infected amid such a large outbreak among birds and other animals, says Marie Culhane, a food animal veterinarian at the University of Minnesota in St. Paul. Still, experts around the globe are diligently watching for any signs the virus may be evolving to spread more easily between people.
The good news is that flu drugs and vaccines that work against the virus already exist, Wille says. Compared with where the world was when the coronavirus behind the COVID-19 pandemic came on the scene, “we are already ahead of the game.”
How the virus would need to change to spread among people is a big unknown This new iteration of bird flu is what’s called a highly pathogenic avian influenza, one that is particularly lethal for both domestic and wild birds. Aquatic birds such as ducks naturally carry avian flus with no or minor signs of infection. But when influenza viruses shuffle between poultry and waterfowl, variants with changes that make them lethal to birds can emerge and spread.
Avian viruses can be severe or even deadly for people. Since 2003, there have been 873 human cases of H5N1 infections reported to the World Health Organization. A little less than half of those people died. In February, an 11-year-old girl in Cambodia died after she developed severe pneumonia from an avian flu virus, the country’s first reported infection since 2014. Her father was also infected with the virus — a different variant than the one behind the widespread outbreak in birds —though he has not developed symptoms. It’s unknown how the two people were exposed.
Some of what scientists know about H5N1’s pandemic potential comes from controversial research on ferrets done more than a decade ago (SN: 6/21/13). Experiments showed that some changes to proteins that help the virus break into cells and make more copies of itself could help the virus travel through the air to infect ferrets, a common laboratory stand-in for humans in influenza research.
While researchers know these mutations are important in lab settings, it’s still unclear how crucial those changes are in the real world, says Jonathan Runstadler, a disease ecologist and virologist at Tufts University’s Cummings School of Veterinary Medicine in North Grafton, Mass. Viruses change constantly, but not all genetic tweaks work together. A change may help one version of the virus transmit better, while also hurting another variant and making it less likely to spread.
“We’re not sure how critical or how big a difference or how much to worry about those mutations when they happen in the wild,” Runstadler says. “Or when they happen five years down the road when there are other changes in the virus’s genetic background that are impacting those [original] mutations.”
That doesn’t stop researchers from trying to pinpoint specific changes. Runstadler and his team look for viruses in nature that have jumped into new animals and work backward to figure out which mutations were crucial. And virologist Louise Moncla says her lab is trying to develop ways to scan entire genetic blueprints of viruses from past outbreaks to look for signatures of a virus that can jump between different animal species.
“There’s a ton that we don’t know about avian influenza viruses and host switching,” says Moncla, of the University of Pennsylvania.
Genetic analyses of H5N1 circulating on the mink farm in Spain, for instance, revealed a change known to help the virus infect mice and mammalian cells grown in the lab. Such a change could make it easier for the virus to spread among mammals, including people. There could have been mink-to-mink transmission on the farm, the researchers concluded, but it remains unclear how much of a role that specific mutation played in the outbreak.
It’s a numbers game for when influenza viruses with the ability to transmit among mammals might make the jump from birds, Runstadler says. “The more chances you give the virus to spill over and adapt, the higher the risk will be that one of those adaptations will be effective [at helping the virus spread among other animals] or take root and be a real problem.”
The ongoing outbreak is still a big problem for birds Irrespective of our inability to forecast human’s future with H5N1, it’s clear that many species of birds — and some other animals that eat them — are dying now. And more species of birds are dying in this outbreak than previous ones, Culhane and Wille say.
“We have seen huge outbreaks in raptors and seabirds, which were never really affected before,” Wille says. It’s possible that genetic changes have helped the virus to spread more efficiently among birds than previous versions of H5N1, but that’s unknown. “There are a number of studies underway to try and figure it out,” Wille says. Historically, these deadly avian flus have not been a persistent problem in the Americas, Moncla says. Sporadic outbreaks of H5N1 variants are typically limited to places such as parts of Asia, where the virus has circulated in birds since its emergence in the late 1990s, and northern Africa.
North America’s last big avian flu outbreak was in 2015, when experts detected more than 200 cases of a different bird flu virus in commercial and backyard poultry across the United States. The poultry industry culled more than 45 million birds to stop that virus’s spread, Culhane says. “But it didn’t go away from the rest of the world.”
The latest version of H5N1 arrived on North American shores from Europe in late 2021, first popping up in Canada in Newfoundland and Labrador. From there, it spread south into the United States, where so far tens of millions of domestic poultry have been culled to prevent transmission on farms where the virus has been detected. By December 2022, the virus had made it to South America. In Peru, tens of thousands of pelicans and more than 700 sea lions have died since mid-January.
It’s important to understand exactly how nonbird animals are getting exposed, Culhane says. Highly pathogenic avian influenzas infect every organ of a bird’s body. So, a fox chowing down on an infected bird is exposing its own mouth, nose and stomach to a lot of virus as it eats its meal.
For now, experts are keeping an eye on infected animals to raise the alarm early if H5N1 starts transmitting among mammals.
“I do think that the mink outbreak, and then the sea lion outbreak, is a wake-up call,” Moncla says. “We should be doing our very best to implement all the science we can to try and understand what’s happening with these viruses so that if the situation does change, we are better prepared.”
LAS VEGAS — It’s a bold claim: The quest to create a superconductor that works under practical conditions is finally fulfilled, a team of researchers says. But controversy has dogged the team’s earlier claim of record-breaking superconductivity, and the new result is already facing extreme scrutiny.
The ultimate test will be whether the result can be confirmed by other researchers, says physicist Mikhail Eremets of the Max Planck Institute for Chemistry in Mainz, Germany. “I repeat it like [a] mantra: ‘Reproduce.’” Many materials become superconductors, able to transmit electricity with no resistance, provided they’re cooled to very low temperatures. A few superconductors work under warmer conditions, but those must be squeezed to crushing pressures, so they’re impractical to use.
Now physicist Ranga Dias of the University of Rochester in New York and colleagues say they have created a superconductor that works at both room temperature and relatively low pressure. A superconductor that operates under such commonplace conditions could herald a new age of high-efficiency machines, supersensitive instrumentation and revolutionary electronics.
“This is the start of the new type of material that’s useful for practical applications,” Dias said March 7 at the American Physical Society meeting, where he reported the feat.
The superconductor is made of hydrogen mixed with nitrogen and a rare earth element called lutetium, Dias and colleagues report March 8 in Nature. The team combined the elements and squeezed them in a device known as a diamond anvil cell. The researchers then varied the pressure and temperature and measured the resistance to electrical flow in the compound.
At temperatures as high as 294 kelvins (about 21° Celsius or 70° Fahrenheit), the material seemed to lose any electrical resistance. It still required pressures of 10 kilobar, which is about 10,000 times the pressure of Earth’s atmosphere. But that’s far lower than the millions of atmospheres of pressure typically required for superconductors that operate near room temperature. If confirmed, that makes the material much more promising for real-world applications.
The material displayed several hallmarks of a superconductor, the team reports. Not only did the electrical resistance suddenly drop as it became superconducting, but the material also expelled magnetic fields and exhibited an abrupt change in its heat capacity, Dias says.
When the researchers put the squeeze on the material in the diamond anvil cell, it suddenly turned from a bluish hue to hot pink. “I had never seen a color change like this in a material,” Dias says. “It was like, wow.” That color change indicated a shift in the electrical properties of the material as it became a superconductor, Dias says. This superconductor might be able to escape the confines of a diamond anvil cell, Dias says, opening it up to practical applications. A technique called strain engineering, for example, could mimic the required pressure. In such a process, researchers grow a material on a surface that constrains growth, putting a strain on the material that replicates the effects of externally applied squeezing.
Still, the research faces significant skepticism, in part because of the firestorm over the team’s earlier publication that claimed the discovery of superconductivity in a compound of carbon, sulfur and hydrogen at 15° C (SN: 10/14/20). Editors at Nature retracted that paper, over the objection of Dias and his coauthors, citing irregularities in the researchers’ data handling that undermined the editors’ confidence in the claims (SN: 10/3/22).
Several experts have expressed a lack of confidence in the new results presented by Dias’ group, based on that history. Not only was the previous result retracted, but other researchers were unable to reproduce it, says Eremets, including his own group at the Max Planck Institute. “The main test of validity — reproducibility — was failed, and from my point of view that’s the most important thing.”
The stakes are high. “If it’s true, it’s a great discovery,” says physicist Eugene Gregoryanz of the University of Edinburgh. But he views the researchers with suspicion. “Whether it’s true or not, I guess time will show.”
Others are more positive. “It’s an excellent study,” says materials chemist Russell Hemley of the University of Illinois Chicago. “The data as presented, in terms of evidence for superconductivity, is very strong.” Hemley was not involved with the study but has collaborated with Dias in the past, including on a follow-up to the retracted superconductor paper. Submitted February 16 at arXiv.org, that paper, which has not yet passed peer-review, reports that the previously claimed superconductor does function near room temperature.
The new superconductor is a hydrogen-rich type known as a hydride. Scientists predict that pure hydrogen should be a room-temperature superconductor, but only at extremely high pressures that make it difficult to produce. To lower the pressure, scientists have added in other elements, making hydride superconductors.
In 2015, Eremets and colleagues produced a compound of sulfur and hydrogen that was superconducting up to −70° C, a record high temperature at the time (SN: 12/15/15). A few years later, a compound of lanthanum and hydrogen was found to superconduct under still chilly conditions, but even closer to room temperature (SN: 9/10/18). Both materials require pressures too high for practical use.
It’s difficult to understand how the new superconductor fits in with other hydrides. Theoretical calculations of how similar hydrides behave wouldn’t suggest that such a material would be superconducting at the reported temperatures and pressures, says theoretical physicist Lilia Boeri of the Sapienza University of Rome. “For me, it looks very strange,” Boeri says. “It’s something completely unexpected…. If it’s true, it’s very different from the other hydrides.”
WASHINGTON — The tale of the first horseback riders may be written on the bones of the ancient Yamnaya people.
Five excavated skeletons dated to about 3000 to 2500 B.C. show clear signs of physical stress that hint these Yamnaya individuals may have frequently ridden horses, researchers reported March 3 at the American Association for the Advancement of Science Annual Meeting and in Science Advances. That makes the Yamnaya the earliest humans identified as likely horseback riders so far. Five thousand years ago, the Yamnaya migrated widely, spreading Indo-European languages and altering the human gene pool across Europe and Asia (SN: 11/15/17; SN: 9/5/19). Their travels eventually stretched from modern-day Hungary to Mongolia, roughly 4,500 kilometers, and are thought to have taken place over only a couple of centuries.
“In many ways, [the Yamnaya] changed the history of Eurasia,” says archaeologist Volker Heyd of the University of Helsinki.
Horse domestication became widely established around 3500 B.C., probably for milk and meat (SN: 7/6/17). Some researchers have suggested the Botai people in modern-day Kazakhstan started riding horses during that time, but that’s debated (SN: 3/5/09). The Yamnaya had horses as well, and archaeologists have speculated that the people probably rode them, but evidence was lacking.
But the oldest known depictions of horseback riding are from about 2000 B.C. Complicating efforts to determine when the behavior emerged, possible riding gear would have been made of long-decayed natural materials, and scientists rarely, if ever, find complete horse skeletons from that time. Heyd and colleagues weren’t seeking evidence of horsemanship. They were working on a massive project called the Yamnaya Impact on Prehistoric Europe to understand every aspect of the people’s lives.
While assessing over 200 human skeletons excavated from countries including Romania, Bulgaria and Hungary, bioanthropologist Martin Trautmann noticed that one individual’s bones carried distinct traits on the femur and elsewhere that he’d seen before. He immediately suspected horseback riding.
“It was just kind of a surprise,” says Trautmann, also of the University of Helsinki.
If it were a one-off case, he says he would have dismissed it. But as he continued analyzing skeletons, he noticed that several had the same traits.
Trautmann, Heyd and colleagues assessed all the skeletons for the presence of six physical signs of horseback riding that have been documented in previous research, a constellation of traits dubbed horsemanship syndrome. These signs included pelvis and femur marks that could have come from the biomechanical stress of sitting with spread legs while holding onto a horse, as well as healed vertebrae damage from injuries that could have come from falling off. The team also created a scoring system to account for the skeletal traits’ severity, preservation and relative importance.
“Bones are living tissue,” Trautmann says. “So they react to any type of environmental stimulus.”
The team deemed five Yamnaya male individuals as frequent horseback riders because they had four or more signs of horsemanship. Nine other Yamnaya males probably rode horses, but the researchers were less confident because the skeletons each displayed only three markers. “Hypothetically speaking, it’s very logical,” says bioarchaeologist Maria Mednikova of the Russian Academy of Sciences in Moscow, who was not involved in the new study. The Yamnaya were very close to horses, she says, so at some point, they probably experimented with riding.
She now plans to check for the horse-riding traits in the Yamnaya skeletons she has access to. “The human skeletal system is like a book — if you have some knowledge, you can read it,” Mednikova says.
Archaeologist Ursula Brosseder, who also was not involved in the work, warns not to interpret this finding as equestrianism reaching its full bloom within the Yamnaya culture. Brosseder, formerly of the University of Bonn in Germany, sees the paper’s discovery as humans still figuring out what they could do with horses as part of early domestication.
As for Heyd, he says he has long suspected that the Yamnaya rode horses, considering that they had the animals and expanded so rapidly across such a large area. “Now, we have proof.”
A form of lightning with a knack for sparking wildfires may surge under climate change.
An analysis of satellite data suggests “hot lightning” — strikes that channel electrical charge for an extended period — may be more likely to set landscapes ablaze than more ephemeral flashes, researchers report February 10 in Nature Communications. Each 1 degree Celsius of warming could spur a 10 percent increase in the most incendiary of these Promethean bolts, boosting their flash rate to about four times per second by 2090 — up from nearly three times per second in 2011. That’s dangerous, warns physicist Francisco Javier Pérez-Invernón of the Institute of Astrophysics of Andalusia in Granada, Spain. “There will be more risk of lightning-ignited wildfires.”
Among all the forces of nature, lightning sets off the most blazes. Flashes that touch down amid minimal or no rainfall — known as dry lightning — are especially effective fire starters. These bolts have initiated some of the most destructive wildfires in recent years, such as the 2020 blazes in California (SN: 12/21/20).
But more than parched circumstances can influence a blast’s ability to spark flames. Field observations and laboratory experiments have suggested the most enduring form of hot lightning — “long continuing current lightning”— may be especially combustible. These strikes channel current for more than 40 milliseconds. Some last longer than one-third of a second — the typical duration of a human eye blink.
“This type of lightning can transport a huge amount of electrical discharge from clouds to the ground or to vegetation,” Pérez-Invernón says. Hot lightning’s flair for fire is analogous to lighting a candle; the more time a wick or vegetation is exposed to incendiary energy, the easier it kindles.
Previous research has proposed lightning may surge under climate change (SN: 11/13/14). But it has remained less clear how hot lightning — and its ability to spark wildfires — might evolve.
Pérez-Invernón and his colleagues examined the relationship between hot lightning and U.S. wildfires, using lightning data collected by a weather satellite and wildfire data from 1992 to 2018.
Long continuing current lightning could have sparked up to 90 percent of the roughly 5,600 blazes encompassed in the analysis, the team found. Since less than 10 percent of all lightning strikes during the summer in the western United States have long continuing current, the relatively high ignition count led the researchers to infer that flashes of hot lightning were more prone to sparking fire than typical bolts. The researchers also probed the repercussions of climate change. They ran computer simulations of the global activity of lightning during 2009 to 2011 and from 2090 to 2095, under a future scenario in which annual greenhouse gas emissions peak in 2080 and then decline.
The team found that in the later period, climate change may boost updraft within thunderstorms, causing hot lightning flashes to increase in frequency to about 4 strikes per second globally — about a 40 percent increase from 2011. Meanwhile, the rate of all cloud-to-ground strikes might increase to nearly 8 flashes per second, a 28 percent increase.
After accounting for changes in precipitation, humidity and temperature, the researchers predicted wildfire risk will significantly increase in Southeast Asia, South America, Africa and Australia, and risk will go up most dramatically in North America and Europe. However, risk may decrease in many polar regions, where rainfall is projected to increase while hot lightning rates remain constant.
It’s valuable to show that risk may evolve differently in different places, says Earth systems scientist Yang Chen of the University of California, Irvine, who was not involved in the study. But, he notes, the analysis uses sparse data from polar regions, so there is a lot of uncertainty. Harnessing additional data from ground-based lightning detectors and other data sources could help, he says. “That [region is] important, because a lot of carbon can be released from permafrost.”
Pérez-Invernón agrees more data will help improve projections of rates of lightning-induced wildfire, not just in the polar regions, but also in Africa, where blazes are common but fire reports are lacking.
